Laboratory Sciences | Charles River Preclinical Services

genetic toxicology 

Genetic toxicology studies are conducted early in the safety testing program of pharmaceuticals, medical devices, chemicals, food additives, etc. Charles River conducts its genetic toxicology studies in a tiered approach, starting with an Ames test and progressing to the conduct of mammalian cell and in vivo assays, which are designed to assess the toxicological relevance of any earlier observations.

Services

  • Cytotoxicity
  • Bacterial mutation (Ames)
  • Chromosome aberration using human lymphocytes or CHO cells
  • Mammalian cell mutation (mouse lymphoma L5178Y TK assay)
  • Rodent micronucleus
  • UDS (in vivo rodent liver and in vitro hepatocyte)
     

In addition, we offer special methods for the following:

  • Evaluating peptides
  • Medical devices
  • Screening for preliminary safety assessment
  • Lead compound identification
  • Mechanistic studies
  • In vitro micronucleus
  • Miniaturized methods for compounds with limited availability
  • Determination of mode of action
  • Target organ testing
  • Gases
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For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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Jun 24-Jun 26 - London, UK - Skin Forum 2013
Jun 21-Jun 25 - Chicago, IL - American Diabetes Association’s 73rd Scientific Sessions
Sep 09-Sep 11 - Carlsbad, CA - 19th Annual Biotechnology-Derived Therapeutics Perspecti...
Jun 28-Jun 28 - Frankfurt, Germany - Seminar: Health Monitoring of Laboratory Animals

Charles River Laboratories, Inc.