Preclinical Toxicology Studies | Charles River

bone research 

Charles River is a world leader in contract bone research, offering a fully integrated service in the field since 1995. We conduct bone safety and efficacy studies using rodent and nonrodent animal models to evaluate osteoporosis drugs. Bone toxicology studies, including bone end points in the toxicological evaluation of new drugs, provide reliable quantitative data on the skeleton. These techniques are applied to meet the requirements for skeletal evaluations in juvenile and neonatal studies. Several animal models are also available to evaluate bone healing.

Charles River routinely performs the following:

  • Radiographic diagnostics (x-ray)
  • Imaging using bone densitometry techniques
  • Biochemical markers of bone and cartilage turnover
  • Histomorphometry and histology
  • Biomechanical strength testing
  • Micro-CT scanning

Recognizing the importance of cartilage and joint integrity, Charles River offers several animal models of arthritis with expertise in intra-articular delivery of test materials.

Animal Models for Bone & Cartilage Evaluations

  • Gonadectomy (ovariectomy and orchiectomy ) -induced bone loss for osteoporosis drug testing
  • 5/6 nephrectomy model
  • TPTx (thyroparathyroidectomy) model
  • Periosteal injection model in weanling rats (screen for anabolic agents)
  • Schenk model in weanling rats (screen for anti-resorptive agents)
  • Bone defect models
  • Orthopedic models
  • Osteoarthritis models
  • Rheumatoid arthritis models

Charles River and WuXi AppTec to Combine

For more information please call:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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News & Events

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Jul 13 - New Genetic Toxicology Assays with...
Jun 09 - Expanded Immunogenicity Testing in...
Jul 29-Jul 29 - Cambridge, MA - Harvard University Life Science Exhibit
Sep 13-Sep 15 - San Diego, CA - Annual Biotech Symposium on Biotechnology-Derived Thera...
Aug 24-Aug 27 - South Carolina, USA - Charles River LAL Workshop
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Charles River Laboratories, Inc.