Charles River has been performing developmental and reproductive toxicity studies for pharmaceutical and biotechnology products for over 30 years. Using internationally recognized guidelines, including International Conference of Harmonization (ICH), we offer overall developmental and reproductive toxicology program planning and individual study design to conduct safety assessments for your products.
Since the emergence of the biotechnology industry in the mid-1980s, Charles River has tested a broad range of biologics and can customize protocols to meet your individual reproductive toxicology requirements. We also offer a complete range of juvenile toxicity testing.
Developmental & Reproductive Toxicology Services
- Developmental reproductive pathology
- Specialized neurobehavioral testing
- Functional assessments including growth (and the skeleton), pulmonary, neurobehavioral, reproductive, and immunological development
- Toxicokinetic evaluations, including induction studies
- Juvenile toxicity testing in rodent and non-rodent species
Specialized DART Study Evaluation Techniques
- Hormone assays
- Male reproductive assessments (rodent and non-rodent)
- Variety of behavioral tests, including activity, learning, and memory, for prenatal and postnatal studies
- Range of developmental immunology tests that can be added to prenatal and postnatal studies
- Endocrine disrupter assessments (uterotrophic assay and Hershberger assay)
- Skeletal measurements for neonatal and juvenile studies (bone size, geometry, and density)
Related DART Test Information
Additional information about our DART capabilities is available in the Source℠, including:
- Historical control data
- Webinar Replay - Assessment of Skeletal Development in Juvenile Toxicology Studies
- Webinar Replay - Reproductive Toxicity Testing: Alternative Animal Models
- Webinar Replay - The Inclusion of Safety Pharmacology and DART Endpoints into Chronic Toxicology Studies
If you have any DART testing questions, please contact us at 1.877.CRIVER.1 or email@example.com.
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