Charles River has performed general toxicology safety evaluation studies for the pharmaceutical, chemical, agrochemical, and consumer product industries for decades. This experience has produced a wealth of knowledge that we can now use to advise and conduct standard and novel toxicology study designs as well as to deal with unexpected findings or toxicity issues during the course of your program.
Our carcinogenicity toxicology studies in rodents and toxicity studies in both rodent and non-rodent species are performed in full compliance with Good Laboratory Practice (GLP) regulations. In addition, all protocols are designed to meet the regulatory requirements of the various countries in which the products are to enter clinical trials or be marketed.
Study Options
Routes of administration:
- Oral (gavage, diet, and capsule)
- Parenteral (intravenous, subcutaneous, intradermal, intramuscular, and intraperitoneal)
- Dermal
- Intranasal
- Intravaginal and intrapenile
- Rectal
- Ocular
- Intra-articular
Species:
Duration:
- Acute to chronic toxicology studies
- Two-year carcinogenicity
- Six-month rasH2, Tg.AC and P53 transgenic
- In utero exposure/neurobehavioral studies
Support Services
- Analytical chemistry for dose formulation analysis
- Bioanalytical chemistry sample assays for drug concentration
- Toxicokinetics and pharmacokinetics
- Specialized statistical analyses
- Scientific and strategic consulting
Additional information about our General Toxicology capabilities is available in The SourceSM, our new online scientific and educational information center. To register for The SourceSM, please click here. If you are already a member, click here to login.
If you have any questions, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.