Preclinical Toxicology Studies | Charles River

general toxicology 

Charles River has performed general toxicology safety evaluation studies for the pharmaceutical, chemical, agrochemical, and consumer product industries for decades. This experience has produced a wealth of knowledge that we can now use to advise and conduct standard and novel toxicology study designs as well as to deal with unexpected findings or toxicity issues during the course of your program.

Our carcinogenicity toxicology studies in rodents and toxicity studies in both rodent and non-rodent species are performed in full compliance with Good Laboratory Practice (GLP) regulations. In addition, all protocols are designed to meet the regulatory requirements of the various countries in which the products are to enter clinical trials or be marketed.

Study Options

Routes of Administration:

  • Oral (gavage, diet, and capsule)
  • Parenteral (intravenous, subcutaneous, intradermal, intramuscular, and intraperitoneal)
  • Dermal
  • Intranasal
  • Intravaginal and intrapenile
  • Rectal
  • Ocular
  • Intra-articular


Species:

  • Rodent
  • Nonrodent 

 
Duration:

  • Acute to chronic toxicology studies
  • Two-year carcinogenicity
  • Six-month rasH2, Tg.AC and P53 transgenic
  • In utero exposure/neurobehavioral studies

 

Support Services

  • Analytical chemistry for dose formulation analysis
  • Bioanalytical chemistry sample assays for drug concentration
  • Pathology Services
  • Toxicokinetics and pharmacokinetics
  • Specialized statistical analyses
  • Scientific and strategic consulting

 

Related Information

Additional information, including a webinar replay titled "The Inclusion of Safety Pharmacology and Reproductive Endpoints into Chronic Toxicology Studies",  is available in the Source
. To register for the Source, please click here. If you are already a member, click here to login.

If you have any questions about our general toxicology services, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.

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For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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Sep 09-Sep 11 - Carlsbad, CA - 19th Annual Biotechnology-Derived Therapeutics Perspecti...
Jun 28-Jun 28 - Frankfurt, Germany - Seminar: Health Monitoring of Laboratory Animals

Charles River Laboratories, Inc.