|
|
Charles River has performed general toxicology safety evaluation studies for the pharmaceutical, chemical, agrochemical, and consumer product industries for decades. This experience has produced a wealth of knowledge that we can now use to advise and conduct standard and novel toxicology study designs as well as to deal with unexpected findings or toxicity issues during the course of your program.
Our carcinogenicity toxicology studies in rodents and toxicity studies in both rodent and non-rodent species are performed in full compliance with Good Laboratory Practice (GLP) regulations. In addition, all protocols are designed to meet the regulatory requirements of the various countries in which the products are to enter clinical trials or be marketed.
Study Options
Routes of Administration:
- Oral (gavage, diet, and capsule)
- Parenteral (intravenous, subcutaneous, intradermal, intramuscular, and intraperitoneal)
- Dermal
- Intranasal
- Intravaginal and intrapenile
- Rectal
- Ocular
- Intra-articular
Species:
Duration:
- Acute to chronic toxicology studies
- Two-year carcinogenicity
- Six-month rasH2, Tg.AC and P53 transgenic
- In utero exposure/neurobehavioral studies
Support Services
- Analytical chemistry for dose formulation analysis
- Bioanalytical chemistry sample assays for drug concentration
- Pathology Services
- Toxicokinetics and pharmacokinetics
- Specialized statistical analyses
- Scientific and strategic consulting
Related Information
Additional information, including a webinar replay titled "The Inclusion of Safety Pharmacology and Reproductive Endpoints into Chronic Toxicology Studies", is available in the Source℠. To register for the Source℠, please click here. If you are already a member, click here to login.
If you have any questions about our general toxicology services, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.
|
General toxicology, general toxicology studies, toxicity testing, toxicology testing, drug safety testing, Acute Toxicology, Acute toxicity testing, acute toxicology studies, repeat-dose toxicity studies, local lymph node assay, Dose Range Finding, no effect level, dose escalation studies, maximum tolerated dose studies, repeat-dose studies, subacute, subchronic, chronic, carcinogenicity testing, carcinogenicity, carcinogenicity studies, carcinogenic potential
General Toxicology Studies | Preclinical Services | Charles River
Charles River has performed general toxicology studies for the safety evaluation of pharmaceuticals for decades. Our carcinogenicity toxicology studies in rodents and toxicity studies in both rodent and nonrodents are fully GLP compliant.