Charles River's dedicated scientific and technical staff has achieved and maintained industry-leading capabilities and a first-class reputation for undertaking both the routine and the most complex infusion toxicology studies. Infusions are either conducted via implanted indwelling catheters or peripheral vein with surgical implantation of the cannula by our experienced surgical staff. Well-established standard operating procedures have permitted the conduct of continuous intravenous infusion studies of up to six months in most species and 12 months in selected animals, making Charles River a world leader in infusion technology. Over the years, additional specialized routes of infusion, continuous or intermittent, and study conducts have been added to our repertoire of capabilities, including:
- Acute to subchronic subcutaneous infusion
- ICH-compliant developmental and reproductive toxicology studies conducted by continuous intravenous infusion
- Intravenous infusion of weanling animals
Routes of parenteral administration, via infusion or injection, have also evolved to include various routes permitting target tissue dosing that include, but are not limited to, the following:
- Intrathecal and epidural
- Intraprostatic injections
Additional information about our Infusion Toxicology capabilities is available in The SourceSM, our new online scientific and educational information center. To register for The SourceSM, please click here. If you are already a member, click here to login.
Subject matter experts are available to answer any questions that you may have regarding infusion toxicology. Click here to submit your specific question, and our scientists will get back to you shortly.