Preclinical Toxicology Studies | Charles River

ocular toxicology 

GLP-compliant ocular toxicology studies have been conducted at Charles River for more than 10 years. This experience, plus the wide variety of equipment, procedures, and parameters available within the Charles River network, provides a service unmatched in our industry. Studies are performed via intravitreal injection, topical instillation, or various systemic routes of exposure in animal models for therapeutic agents targeting a range of diseases and conditions, such as:

  • Age-related macular degeneration (AMD)
  • Diabetic retinopathy
  • Glaucoma
  • Dry eye
  • CMV retinitis
  • Uveitis
  • Hemorrhage clearance
  • Ocular side effect (e.g., PDE5/PDE6 inhibitors)

Specialized services to support your ocular program include:

  • Electroretinography
  • Tonometry (IOP) evaluations
  • Digital fundus photography
    • Multiple image modes (infrared and tomography for 3D images)
    • Autoreflectance
    • Fluorescein angiography (FA)
    • Indocyanine green (ICG)
  • Vitrectomy
  • Quantitative autoradiography
  • Drug metabolism techniques
  • Enhanced microscopic evaluation
  • Light- and laser-induced efficacy models
Discover the full range of Charles River Products and Services

For more information please call:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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News & Events

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Mar 09 - New Endotoxin Data Management Soft...
Mar 08 - Rodent Intravenous Infusion Capabi...
Apr 07-Apr 10 - La Grande Motte, France - Perspectives in Percutaneous Penetration: 12t...
Mar 22-Mar 23 - San Francisco, CA - 2010 PMF Bacterial Endotoxin Summit
May 05-May 05 - Tempe, AZ - Rodent Colony and Disease Management Considerations – A Sem...
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Veterinary Pathologist II Reno, NV
Corporate Sr. VP, Corporate Development 

Charles River Laboratories, Inc.