Preclinical Toxicology Studies | Charles River

toxicokinetics 

We provide bioanalytical support for samples generated in toxicology studies, and the resultant test material concentration data can be interpreted by our Pharmacokinetics staff using industry-standard WinNonlin® software. Both non-compartmental and compartmental approaches are available. We offer this as an integrated service, where all aspects of the study are managed within our own laboratories, or as a stand-alone service, which enables analysis of concentration data generated elsewhere by the sponsor.

Toxicokinetic parameter estimation output includes a comprehensive text interpretation of the data, as required.

In addition, we can address preclinical-to-clinical considerations (e.g., allometric scaling) when planning first-in-human studies.

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For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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