ORIGINTransgenic mice were produced by injecting an 11.8 kb (NotI fragment) human genomic GLUT 4 transgene including a 5.3 kb of 5’flanking sequence and an SV40 polyadenylation sequence into the pronuclei of embryos from matings of C57BL/KsJ-m+/+ males and superovulated females. The embryos were then transferred to pseudopregnant CD-1 females. Founder mice were identified by PCR of total genomic DNA to obtain two mice with the recessive obese phenotype (+db/+db) and two founders with the recessive misty coat color (m+/m+). Independent lines were established by backcrossing lean founder mice with C57BL/KsJ-m+/db+ mates. Transferred to Charles River under exclusive license in 2011.
STRAIN CODEComing Soon
MUTATION INFORMATIONNon-insulin-dependent diabetes mellitus (NIDDM) is characterized by hyperglycemia in both fed and fasted states and is manifested by defects in both insulin secretion from the pancreas and insulin action in the peripheral tissue (liver, skeletal muscle and adipose tissue). The defect in transport cannot be attributed solely to the expression of the major transporter GLUT 4, as little or no reduction in GLU4 levels are observed in NIDDM patients. Db/db mice mimic the human disease, including hyperglycemia, insulin resistance and obesity, and show a marked decrease in skeletal muscle utilization without an accompanying decrease in GLUT 4 expression.
This model evaluates the effect of overexpression of GLUT 4 to reduce hyperglycemia and improve glycemic control.
Features of the Model
ORDERING INFORMATIONPlease call 1.800.LAB.RATS if you would like to place an order.
For additional information about GLUT 4 mice, please contact Technical Services at 1.877.CRIVER.1 (1.877.274.8371) or email@example.com.
DISCLAIMERGLUT 4 mice may be subject to the licensed patents and are sold only for research purposes under agreement from Pfizer, Inc.
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Clinical pathology data can assist you in selecting the most appropriate model for your study and can provide important information on the physiology and health of your research animals.
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This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.