Research Animal Models | Charles River

research animal models




overviewpricing & literature
NIH-III Nude mouse

NIH-III Nude Mouse

Crl:NIH-Lyst bgFoxn1nuBtk xid

 

ORIGIN
Most commonly called the NIH-III, it was developed at NIH. In addition to the nude gene, which results in the absence of thymus and T-cell function, this mouse has two other mutations important in regulating the function of the immune system. These are designated as x-linked immune defect (xid) and beige (bg). The xid mutation affects the maturation of T-independent B lymphocytes. It has been demonstrated that bg homozygotes have defective natural killer (NK) cells that are cytotoxic in vitro to tumor cells. However, the extent of the T-independent B lymphocyte and NK cell deficiencies in the NIH-III have not been established.

STRAIN CODE 201 (HOMOZYGOUS),
202 (HETEROZYGOUS*)
*Heterozygous animals are not immunodeficient and are haired.

COAT COLOR Hairless, light to dark gray pigmented skin

RESEARCH APPLICATION
tumor biology and xenograft research

BREEDING LOCATION
US

ORDERING INFORMATION
Please call 1.800.LAB.RATS if you would like to place an order.

For additional information about NIH-III Nude mice, please contact Technical Services at 1.800.338.9680 or comments@crl.com.


Discover the full range of Charles River Products and Services
The Source

For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

view all

News & Events

view all
May 08 - Access Xenograft Data for Immunode...
May 01 - New GEMS Webinars Now Available On...
Jun 02-Jun 05 - Vancouver, British Columbia - CALAS
Jun 18-Jun 21 - Newton, MA - 2012 Charles River Short Course on Laboratory Animal Scien...
Jun 05-Jun 08 - Saint Germain sur l’Arbresle, France - Charles River LAL Seminar Series
view all
Scientist I Wilmington, MA
Manager International Tax Wilmington, MA

Charles River Laboratories, Inc.