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PCK Rat: The Pkhd1 gene mutation in this animal model mimics human autosomal-recessive polycystic kidney disease (ARPKD).

PCK Rat

PCK/CrljCrl-Pkhd1pck/CRL

ORIGIN
This model of polycystic kidney disease showing both kidney and liver involvement was identified in a colony of CD rats from the Charles River Japan production facility. The identification of the Pkhd1 gene mutation was reported by Katsuyama and associates in 2000. This autosomal recessive Pkhd1 gene mutation is a model of human autosomal-recessive polycystic kidney disease (ARPKD). To Charles River Laboratories in 2006.

STRAIN CODE 453

COAT COLOR White (albino)

RESEARCH APPLICATION
polycystic kidney disease, autosomal recessive trait

ORDERING INFORMATION
Please call 1.800.LAB.RATS if you would like to place an order.

For additional information about PCK rats, please contact Technical Services at 1.800.338.9680 or comments@crl.com.


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