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THE POUND MOUSE™: a pre-diabetes/metabolic syndrome model

THE POUND MOUSE™

C57BL/6NCrl-Leprdb-lb/Crl

ORIGIN
This model was isolated from a C57BL/6NCrl colony in a Charles River Laboratories barrier facility in the United States in 2005. The mutation was mapped to a region within less than 2 cM of the leptin receptor on Chr 4. Lack of leptin receptor protein. Het x Het mating.

STRAIN CODE 457 (OBESE), 464 (LEAN +/?)

COAT COLOR Black

RESEARCH APPLICATION
obesity, hyperinsulinemia, insulin resistance, dyslipidemia, metabolic syndrome, leptin receptor deficiency, fatty liver disease

CONTROL THE POUND MOUSE™ lean or the standard C57BL/6NCrl

ORDERING INFORMATION
Please call 1.800.LAB.RATS if you would like to place an order.

For additional information about THE POUND MOUSE™, please contact Technical Services at 1.800.338.9680 or comments@crl.com.


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