Research Animal Models | Charles River

disease & translational models 

 
 

Models are listed according to their therapeutic area, but some may be used for several indications. Click here for more information.

Cardiovascular Research Models CNS Research Models
Diabetes Research Models Immunology and Inflammation Research Models
Metabolism and Regulation Research Models Oncology Research Models

Cardiovascular Research Models

Common Name Nomenclature Species
11BHSD2* C57BL/6NCrl-Tg(aMhc-Hsd11b2) Mouse
APOA1* B6;CBA-Tg(APOA1)427Bres/Crl Mouse
LOX-1* C57/BL6J-Tg(OLR1) Mouse
Spontaneously Hypertensive Heart Failure (SHHF)$ SHHF/MccGmiCrl-Leprcp/Crl Rat
Click here for surgically altered cardiovascular models.
CNS Research Models
Common Name Nomenclature Species
NSE-p25* FVB/N-Tg(Eno2-CDKSr1)1Jdm Mouse
P-glycoprotein Deficient (PGP) Crl:CF1-Abcb1amds Mouse
Click here for surgically altered CNS models.
Diabetes Research Models
Common Name Nomenclature Species
GLUT 4* C57BL/KsJ-db/db-Tg(SLC2a4)1Jdm Mouse
Goto-Kakizaki (GK)$ GK/TohiCskCrljCrl Rat
GSK3B* FVB/N-Tg(Mic2-tTA-GSK3) Mouse
Spontaneously Hypertensive Heart Failure (SHHF)$ SHHF/MccGmiCrl-Leprcp/Crl Rat
Rip-HAT* FVB/N-Tg(Ins2-IAPP)RHF Soel Mouse
RIP-HAT* CD:SD-Tg(ins2-IAPP)Soel Rat
ZSF1$ ZSF1-LeprfaLeprcp/Crl Rat
Zucker Diabetic Fatty (ZDF)$€ ZDF-Leprfa/Crl Rat
Immunology and Inflammation Research Models
Common Name Nomenclature Species
Ly5$€ B6.SJL-PtprcaPepcb/BoyCrl Mouse
MMP9* FVB/N-Tg(Eno2-MMP9) Mouse
OT I C57BL/6-Tg(TcraTcrb)1100Mjb/Crl Mouse
OT II C57BL/6-Tg(TcraTcrb)425Cbn/Crl Mouse
Metabolism and Regulation Research Models
Common Name Nomenclature Species
Bcrp$ Crl:WI(UL)-Abcg2tm1/Hubr Rat
Dahl/Salt Sensitive (DAHL/SS)$ SS/JrHsdMcwiCrl Rat
Goto-Kakizaki (GK)$ GK/TohiCskCrljCrl Rat
HSD11B1* FVB/N-Tg(AP2-HSD11b1) Mouse
LCAT* C57BL/6J-Tg(Alb-LCAT)1Jdm Mouse
Obese Prone CD (OP-CD)$ Crl:OP(CD) Rat
Obese Resistant CD (OR-CD)$ Crl:OR(CD) Rat
PCSK9* C57BL/6J-Tg(ALB-PCSK9) Mouse
Spontaneously Hypertensive Heart Failure (SHHF)$ SHHF/MccGmiCrl-Leprcp/Crl Rat
Spontaneously Hypertensive (SHR)$€ SHR/NCrl Rat
Spontaneously Hypertensive Obese (SHROB)$ SHROB/KolGmiCrl-Leprcp/Crl$ Rat
Spontaneously Hypertensive Stroke Prone (SHRSP)$ SHRSP/A3NCrl Rat
THE POUND MOUSE$€ C57BL/6NCrl-Leprdb-lb/Crl Mouse
ZSF1$ ZSF1-LeprfaLeprcp/Crl Rat
Zucker$€ Crl:ZUC-Leprfa Rat
Zucker Diabetic Fatty (ZDF)$€ ZDF-Leprfa/Crl Rat
Oncology Research Models
Common Name Nomenclature Species
129 D931A* 129P2.B6J-Pik3cbtm3Bvan/Crl Mouse
129 flox* 129P2.B6J-Pik3cbtm1.1Bvan/Crl Mouse
AKR* AKR/NCrl Mouse
B6 D910A* B6J.129P2-Pik3cdtm2Bvan/Crl Mouse
B6 D931A* B6J.129P2-Pik3cbtm3Bvan/Crl Mouse
B6 D933A* B6J.129P2-Pik3catm2Bvan/Crl Mouse
B6 flox* B6J.129P2-Pik3cbtm1.1Bvan/Crl Mouse
B6 lacZ* B6J.129P2-Pik3catm3Bvan/Crl Mouse
B6 lacZ D931A* B6J.129P2-Pik3cbtm2Bvan/Crl Mouse
B6 S1031A* B6J.129P2-Pik3cdtm3Bvan/Crl Mouse
BDIX* BDIX/CrCrl Rat
Buffalo$ BUF/CrCrl Rat
C D910A* C.129P2(B6)-Pik3cdtm2Bvan/Crl Mouse
C D931A* C.129P2(B6)-Pik3cbtm3Bvan/Crl Mouse
Immortomouse®$ CBA;B10-Tg(H2Kb-tsA58)6Kio/Crl Mouse
lacZ* B6J.129P2-Pik3cdtm1Bvan/Crl Mouse
Noble* NBL/CrCrl Rat
p110alpha flox* B6J.129P2-Pik3catm1Bvan/Crl Mouse
p110beta flox* B6J.129P2-Pik3cbtm1Bvan/Crl Mouse
p53$ Crl:WI(UL)-Tp53tm1/Hubr Rat
Wistar Furth* WF/CrCrl Rat

$€ Bred in U.S. and E.U.
$ Bred in U.S.
€ Bred in E.U.
*Cryopreserved


Deltagen Repository

Charles River is pleased to be the exclusive custodian and distributor of Deltagen's repository of knockout mouse lines. Deltagen, Inc. has approximately 900 lines of knockout mice available for licensing to the research community.

For more information on Deltagen's products, visit www.deltagen.com or email deltaone@deltagen.com.


Model In-licensing

Interested in licensing your line to Charles River for distribution?  Visit our model licensing section to find out more.

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