We know that having animals on a defined genetic background is important for your research but the time it takes to fully backcross a novel model can be prohibitive. To help you further your research more quickly, we offer an advanced speed congenics program called MAX-BAX®. MAX-BAX® (Marker-Assisted Accelerated Backcrossing) can facilitate the rapid production of congenic strains of knockout or transgenic animals through the use of microsatellite analysis. This pioneering process selects individuals with preferred genetic backgrounds and greatly reduces the number of generations needed to produce a congenic research model. Backcrossing guided by our microsatellite analysis data achieves 99.9% congenicity in approximately five generations, potentially saving you up to 1.5 years of breeding time (five generations) over conventional backcrossing. We offer approximately two dozen panels of 96-110 microsatellite markers for a variety of the most popular inbred strain comparisons, and can develop new panels on demand at no charge.
The MAX-BAX® program is available to you either as a standalone service or in conjunction with our in-house breeding services. When performed as a standalone service, you submit a small tissue sample (typically ear or tail) or purified DNA to our facility, we perform the microsatellite analysis, and return the data to you with recommendations on which animals to breed in the next generation. We recommend reading our breeding guidelines for more information. When performed in conjunction with our breeding services, each client is assigned a dedicated project manager who will direct all aspects of the breeding and genotyping. As a fully managed program, all you need to do is submit animals for MAX-BAX® and we will return fully congenic animals in approximately 15 months.
For more information, contact us at:
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Clinical pathology data can assist you in selecting the most appropriate model for your study and can provide important information on the physiology and health of your research animals.
We are now the exclusive distributor of the TARGATT™ mouse. The TARGATT mouse is a transgenic mouse designed to produce animal models with investigator designed exogenous DNA sequences knocked-in to a specific site.
Jun 10–Jun 13
Visit us in booth #091 to learn more about our recent innovations including expanded diagnostic capabilities, a new online portal connecting clients with their colonies and a deep-rooted commitment to humane care.
May 20–May 22
Please visit Charles River tabletop #611 to discuss our full portfolio of products and services, including our Preclinical Services, as well as our Biopharmaceutical Services, which deliver client-focused solutions for the specific testing and manufacturing requirements of your biologic.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.