Supporting the Research Community by Creating and Phenotyping Knockout Mouse Mutants to Provide Functional Annotation for Protein-Coding Genes
Funded by the NIH as part of the second phase of the Knockout Mouse Project (KOMP2), the DTCC Consortium is creating a repository of knockout mouse lines and phenotype data as part of an international effort to help researchers develop better models of human disease. University of California, Davis (UC Davis), Toronto Centre for Phenogenomics (TCP), Children’s Hospital Oakland Research Institute (CHORI) and Charles River have come together to form the DTCC Consortium for this 5-year research effort. In addition to the DTCC Consortium, the other KOMP2 participants include The Jackson Laboratory as well as the collaboration of Baylor College of Medicine, the Wellcome Trust Sanger Institute and the Medical Research Council (MRC) Harwell.
Click here to listen to a 5 minute podcast introducing the DTCC and its mission.
Click here to learn how the DTCC Consortium supports the KOMP2 through production and phenotyping of mutant mouse lines.
| Strengthen Your Research with the DTCC Consortium
In collaboration with your internal scientific development team, the DTCC Consortium can provide additional breadth and depth to your model analysis to determine the suitability of a model or target to meet your specific research needs.
The DTCC Consortium offers access to the phenotyping platform used on the mutant mouse models as well as additional specialized phenotyping platforms at our facilities, including:
- Comprehensive gross necropsy and histopathology
- Additional behavioral testing, including learning and memory
- Multimodality imaging of adult animals
- Metabolic phenotyping
The DTCC can also assist in accessing models developed at the other International Mouse Phenotyping Consortium (IMPC) centers whose primary phenotyping results reveal phenotypes of interest to your scientific development team. In addition, our frozen and fixed tissue bank is available for collaborative and follow-up evaluation. To discuss your research or a potential collaboration with the DTCC Consortium, please contact us at dtcc@komp.org.
Helping the DTCC Build a Stronger Mutant Mouse Model Repository
To maximize the value of the DTCC Consortium effort, we want to know about the therapeutic areas, disease models and phenotyping information of interest to you. Further, we welcome suggestions from the scientific community to help us grow. This includes input regarding our phenotyping program, nominations of genes for model development and suggestions on focal areas in specific research. Contact us at dtcc@komp.org.
|
|
- Inflammation and infection
|
University of California, Davis | Toronto Centre for Phenogenomics | Children's Hospital Oakland Research Institute | Charles River
dtcc, dtcc consortium, KOMP@, knockout, knock out, mutant mouse, mutan, phenotyping, necropsy, histophatholgy, behavioral testing, multimodality, metabolic phenotyping, IMPC, tissue bank, NIH, national institute of health, UC Davis, CHORI, TCP, University of California, Davis, Toronto Centre for Phenogenomics, Children’s Hospital Oakland Research Institute, knockout mouse lines, knockout mouse
DTCC Consortium | Charles River
The DTCC Consortium is creating a repository of knockout mouse lines and phenotype data as part of an international effort to help researchers develop better models of human disease.