Now Available: New Fast and Cost-Effective Methods for the Evaluation of Inner Ear Structures
July 26, 2012 - Evaluation of inner ear structures is becoming increasingly important in toxicologic pathology. Charles River is now offering small and large animal model inner ear histopathology and immunohistochemistry.
Many chemicals, including numerous drugs, are known to cause damage to the inner ear. In the past, the structures of the inner ear have often been ignored in toxicologic pathology, in part because of the technical challenges associated with their examination. Following a growing interest in the development of drugs and gene therapies targeting hearing impairment, histopathological evaluation of inner ear structures, particularly the cochlear and vestibular hair cells, is becoming an important tool in toxicologic pathology.
Charles River has developed fast and cost-effective methods for the fixation, decalcification and trimming of both small and large animal models' inner ears. These new methods allow us to obtain very good cellular preservation and section quality without having to use complex and expensive approaches such as whole-body perfusion and plastic embedding.
These new services may include, for example, assessment of inner ear lesions in toxicity studies, injury models and immunohistochemical marking for visualization of specific cell types (e.g., hair cells) or for viral vector distribution.
To learn more about our new methods for the evaluation of inner ear structures, please contact us at askcharlesriver@crl.com.
Related Information
- Pathology Services
- Poster: Processing of Large Animal Inner Ear for Histopathological Evaluation (Available only on The Source℠. Click here to log in or click here to register.)
- Poster: Processing of Rodent Inner Ear for Histopathological Evaluation (Available only on The Source℠. Click here to log in or click here to register.)