New Optical Imaging Technology Now Offered as Part of Ophthalmology Research Services
June 24, 2009 – In keeping with our tradition of cutting-edge science and innovation, Charles River Preclinical Services Montreal now offers spectral-domain optical coherence tomography (SD-OCT) combined with a confocal scanning laser ophthalmoscope for retinal evaluations. This technology provides the ability to obtain cross-sectional (B-scan) images of the retina to a resolution of 1µm.
The method is non-invasive and can be performed numerous times over the course of a study to obtain longitudinal data on the cell layers within the retina. The instrument can record individual two-dimensional slices in discrete regions or can perform volume scans of larger regions that can be viewed and evaluated as individual slices or as a complete three-dimensional image. Measurements can be made manually or automatically within the cross-sections, and retinal thickness maps can be generated for comparison over time.
A compare function allows for precise return for follow up to regions of interest that had been imaged previously. This instrument will be used to support preclinical ocular toxicology studies when local delivery to the retina is required and to support observations related to retinal morphology or function obtained by other means (e.g., clinical ophthalmology examinations, ERG).
It will also be used to aid in the characterization of ocular models of retinal degeneration or disease such as laser-induced choroidal neovascularization, diabetic retinopathy and light-induced retinal degeneration and to support general toxicology studies when there is a concern for adverse ocular side effects or to elucidate unexpected ocular changes.
For more information about our new SD-OCT offering or any of our preclinical services, contact us at 1.877.CRIVER.1 (1.877.274.8371) or askcharlesriver@crl.com.
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