| |
|
|
|
| |
Study on Rat MI Model Yields Results
2011 Charles River study shows ischemic lesion can be reliably produced in 70% of rat myocardial infarction models
October 20, 2011 - Coronary artery disease is the leading cause of death worldwide. The primary cause of this disease and subsequent heart failure is atherosclerosis of coronary arteries leading to occlusion and ischemic damage to the heart muscle.
Charles River Surgical Services performed a study to characterize the rat myocardial infarction model. The goal of the project was to document the expected size of ischemic lesion following ligation of the left anterior descending (LAD) coronary artery in the CD® rat. Forty-two male CD® rats [Crl:CD(SD)] weighing 175-200 grams underwent surgical ligation of the LAD coronary artery, followed by measurement of the resulting ischemic lesion. Results showed that an ischemic lesion comprising 20-30% of total cardiac tissue can be reliably produced in at least 70% of the animals that underwent surgery.
For further information on this study, please click here.
Related Information
|
|
Myocardial Infarction, MI, ischemic lesion, CD, Coronary artery disease, heart failure, atherosclerosis, coronary arteries, occlusion, ischemic, heart, Surgical, surgery, ligation, left anterior descending, LAD, coronary artery, cardiac
Study on Rat Myocardial Infarction (MI) Model Yields Results | Charles River
Charles River performed a study to characterize the rat myocardial infarction (MI) model by documenting the expected size of ischemic lesion following ligation of the left anterior descending (LAD) coronary artery in the CD rat.