Diet-Induced Obesity & Dyslipidemia Models
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In diet-induced obesity studies, conventional animals (rats or mice) are fed high-fat diets to induce weight gain, diabetes, high blood pressure, dyslipidemia and other obesity phenotypes. Monitoring of serum lipids, leptin, glucose, insulin, glucagon and vascular complications can be incorporated in study design for expanded data results. Use of serum lipid/lipoprotein measurements as related to atherosclerosis and metabolic syndromes may be used to assess a number of different lipid-lowering agents. Adding a high percentage of carbohydrate such as sucrose or fructose in high-fat diets leads to the induction of hyperlipidemia in rats and can be used to test the efficacy of hypolipidemic agents.
Our ability to combine standard physiological assays, histopathology, plasma biomarkers and imaging capabilities set Charles River apart as a premium provider for the assessment of agents intended to treat these metabolic disorders.
For more information about our diet-induced obesity and dyslipidemia models, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.
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diet-induced obesity, dyslipidemia, obesity, lipids, leptin, glucose, insulin, glucagon, lipoproteins, metabolic syndrome, hyperlipidemia, hypolipidemic, metabolic disorders
Diet-induced Obesity and Dyslipidemia Models | Charles River
In diet-induced obesity studies, animals are fed high-fat diets to induce diabetes, high blood pressure, dyslipidemia, etc. Monitoring of serum lipids, leptin, glucose, insulin, glucagon and vascular complications can be incorporated in study design.