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GLP-compliant ocular toxicology studies have been conducted at Charles River for more than 10 years. This experience, plus the wide variety of equipment, procedures, and parameters available within the Charles River network, provides a service unmatched in our industry. Studies are performed via intravitreal injection, topical instillation, or various systemic routes of exposure in animal models for therapeutic agents targeting a range of diseases and conditions, such as:
- Age-related macular degeneration (AMD)
- Diabetic retinopathy
- Glaucoma
- Dry eye
- CMV retinitis
- Uveitis
- Hemorrhage clearance
- Ocular side effect (e.g., PDE5/PDE6 inhibitors)
Specialized services to support your ocular program include:
- NEW! Specular microscopy for non-invasive, in vivo evaluation of the corneal endothelium
- Electroretinography
- Tonometry (IOP) evaluations
- Digital fundus photography
- Multiple image modes (infrared and tomography for 3D images)
- Autoreflectance
- Fluorescein angiography (FA)
- Indocyanine green (ICG)
- Vitrectomy
- Quantitative autoradiography
- Drug metabolism techniques
- Enhanced microscopic evaluation
- Light- and laser-induced efficacy models
Additional information about our Ocular Toxicology capabilities is available in The SourceSM, our new online scientific and educational information center. To register for The SourceSM, please click here. If you are already a member, click here to login.
 Subject matter experts are available to answer any questions that you may have regarding ocular toxicology. Click here to submit your specific question, and our scientists will get back to you shortly.
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Ocular Toxicology Studies | Preclinical Testing Services | Charles River
Charles River conducts GLP-compliant ocular toxicology studies. Studies are performed via intravitreal injection, topical instillation, or various systemic routes of exposure in multiple species, including ophthalmic disease-specific animal models.