We provide bioanalytical support for samples generated in toxicology studies, and the resultant test material concentration data can be interpreted by our Pharmacokinetics staff using industry-standard WinNonlin® software. Both non-compartmental and compartmental approaches are available. We offer this as an integrated service, where all aspects of the study are managed within our own laboratories, or as a stand-alone service, which enables analysis of concentration data generated elsewhere by the sponsor.
Toxicokinetic parameter estimation output includes a comprehensive text interpretation of the data, as required.
In addition, we can address preclinical-to-clinical considerations (e.g., allometric scaling) when planning first-in-human studies.