ORIGIN
In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), that were developed in conjunction with Merck by Charles River Genetically Engineered Models and Services in Wilmington, MA.
STRAIN CODE 291
BREEDING LOCATION
US
COAT COLOR White (albino)
RESEARCH APPLICATION
PGP-deficient blood brain barrier model, CNS, transport/excretion involving mds (multiple drug sensitive) for neurobiology and chemotherapy, toxicology, teratology, altered intestinal intraepithelial lymphocyte development
ORDERING INFORMATION
Please call 1.800.LAB.RATS if you would like to place an order.
For additional information about PGP mice, please contact Technical Service at 1.800.338.9680 or comments@crl.com.
Note: Wild-type CF-1 mice are available from barrier colonies under strain code 023 and from isolator colonies under strain code 292.