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Spontaneously Hypertensive Heart Failure (SHHF) Rat: a model developed by backcrossing the SHROB rat to the SHR/N rat

Spontaneously Hypertensive Heart Failure (SHHF) Rat

SHHF/MccGmiCrl-Lepr cp/Crl

ORIGIN
Breeding stock for this colony was transferred to Dr. Sylvia McCune at the University of Chicago Medical School in 1983 from the laboratory of J.E. Miller at G.D. Searle and Company. The animals were developed by backcrossing the SHROB rat to the SHR/N rat. Dr. McCune obtained the colony after the seventh backcross and continued to inbreed past 20 generations to fix the congestive heart failure trait. To Genetic Models, Inc. in 1994. To Charles River in 2001.

STRAIN CODE 373 (OBESE), 374 (LEAN +/?)

COAT COLOR White (albino)

RESEARCH APPLICATION
heart failure, hypertension, Type 2 diabetes, nephropathy, insulin resistance

CONTROL SHHF Lean

BREEDING LOCATION
US

ORDERING INFORMATION
Note: Model available in limited supply. Please call 1.800.LAB.RATS if you would like to place an order.

For additional information about Spontaneously Hypertensive Heart Failure (SHHF) rats, please contact Technical Services at 1.800.338.9680 or comments@crl.com.


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