New Endpoints Available for Assessment of Muscle and Peripheral Nerve Components of the Locomotor System
May 10, 2012 - In response to the growing interest in restoring or preserving not only bone quality but also muscle function in aging or debilitated people, Charles River is expanding our focus beyond the evaluation of bones to now also include other components of the locomotor system. Our new offerings include various novel applications of imaging, biochemical and histomorphometric modalities, as well as electrophysiology measurements (nerve conduction and electromyography) to evaluate the locomotor unit. This expanded focus will allow us to characterize either pharmacologic or adverse effects of xenobiotics.
We have completed studies in adult orchidectomized rats and large animal models that can be used to test compounds with a potential to treat or prevent sarcopenia induced by androgen deficiency. The physiological response to the decline in steroid hormones mimics the natural progression of aging, providing superior models to those induced by surgery or drug intervention. The results show that in vivo DXA and pQCT imaging can be used to monitor decreases in lean muscle area and bone mineral density in these models. Nerve and muscle action potential were successfully performed in the rat model. The monitored muscular effects were comparable to those obtained from individual muscles dissected and weighed from the same region.
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We offer a package of well-established, state of the art in vitro mode of action assays that are suitable for early phase biocomparability studies, lot release and stability. These tests can accelerate the time it takes to get a new product ready for market submission.
Charles River has developed and optimized the RT-PCR test for vertically-transmitted poultry pathogens for testing SPF flocks as defined by the PhEur 5.2.2.
mai 21–mai 24
RDD Europe 2013 is a forum for pulmonary and nasal drug delivery experts from all around the world to exchange scientific knowledge and expertise.
mai 23–mai 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
Charles River Laboratories, Inc.