New Evaluations Available to Study Effect of Drugs on Platelet Numbers and Function
July 10, 2012 - Because platelets are the first line of defense against vascular bleeding and are major contributors to thrombosis and inflammation, observation of decreases in platelet counts and/or alterations in platelet function are important findings in regulatory preclinical studies.
The immunology and clinical pathology groups at Charles River provide services to support your need to evaluate the potential effect of your compound on platelet numbers and/or function. Our experience includes evaluation of various types of test articles, including, but not limited to, monoclonal antibodies, small molecules, proteins and peptides.
The methods listed below are offered by Charles River and allow for the evaluation of drug-induced platelet decreases and dysfunction.
Evaluation of Decreased Platelet Counts:
Evaluation of Platelet Function:
To learn more about incorporating platelet evaluations into your research, please contact us at email@example.com.
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The development of reliable inflammatory markers and in vitro assays capable of predicting in vivo cytokine release could help reduce study costs and the number of animals used for toxicology studies.
We now offer several new evaluation methods that allow for the observation of decreases in platelet counts and/or alterations in platelet function in order to monitor the efficacy or potential undesired drug effects on platelets.
We have established an in vivo screening platform to provide fast and cost-effective screening of compound effects on motor behavior and brain functionality for the study for central nervous system diseases.
mai 28–juin 01
The International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) are excited to sponsor the second joint scientific meeting by the two organizations.
mai 23–mai 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
Charles River Laboratories, Inc.