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Charles River to Supply Pfizer's Genetically Modified Research Models

March 3, 2011 - Charles River has entered into a marketing and distribution agreement with Pfizer, Inc., to provide certain Pfizer-developed genetically modified research models to the global biomedical research community. The Pfizer strains encompass several different therapeutic areas, including CNS, diabetes, inflammation and cardiovascular disease. The table below contains general details on each strain. Additional information can be accessed by clicking on each strain line’s name or the corresponding publication link (if available).

Line  Species Therapeutic Area  Publication
RIP-HAT  Rat Diabetes  Publication
11BHSD2   Mouse Cardiac hypertrophy, heart failure  Publication
PCSK9   Mouse Cholesterol regulation  Publication
GLUT 4  Mouse Diabetes  Publication
MMP9  Mouse Inflammation, extracellular remodeling  On Request
GSK3B   Mouse Glycogen regulation; diabetes   N/A
LCAT  Mouse Cholesterol efflux, esterification and transport   Publication
HSD11B1   Mouse Cortisone regulation  N/A
NSE-p25   Mouse Alzheimer's disease Publication 
Rip-HAT  Mouse Diabetes Publication 
Lox-1  Mouse Cardiovascular  N/A

The ordering process is simple and straightforward, and our team of animal specialists can work with you to make all the necessary shipping arrangements and answer any questions you may have. As an industry leader in colony development and animal production services, we are pleased to feature these valuable Pfizer strains in our growing portfolio of research models and animal support services.

For more information or to receive a quote, please contact us at askcharlesriver@crl.com.

Note: These models may be subject to the licensed patents and are sold only for research purposes under agreement from Pfizer, Inc.

   
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askcharlesriver@crl.com

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Charles River Laboratories, Inc.