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New therapies to promote bone healing or treat osteoporosis, arthritis, and other skeletal diseases require a comprehensive preclinical assessment of bone and cartilage. Bone end points can be incorporated into toxicology programs to fully evaluate test articles that have an intended effect on bone or to determine effects of test articles that have secondary, indirect, or adverse effects.
Charles River offers services in the area of bone/skeletal research that combine established discovery, preclinical, and clinical program development expertise with a host of novel bone research technologies that provide highly specialized evaluations of bone disease and bone quality. Our scientists can assess the effect of a drug in vivo or ex vivo on bone at toxicological and pharmacological doses and facilitate the interpretation of study findings to help you better design clinical trials.
Services
- In vivo preclinical studies
- Research models and services
- Animal models for bone and cartilage evaluations
- Ovariectomy-induced bone loss
- 5/6 nephrectomy model
- TPTx (thyroparathyroidectomy) model
- Periosteal injection
- Schenk model
- Bone defect
- Orthopedic
- Osteoarthritis
- Rheumatoid arthritis
- Formulation development, preparation, and analysis
- Novel surgical techniques
- Radiography
- Bone densitometry
- Biochemical markers of bone turnover
- Preclinical and clinical samples
- Multiple species
- Formation markers
- Resorption markers
- Hormone assays
- Dual-Energy X-Ray Absorptiometry (DXA)
- Peripheral Quantitative Computed Tomography (pQCT)
- Histomorphometry
- Biomechanics
- Micro-CT
- Navigator consulting services
- Laboratory sciences
- Phase I clinical trials
- Central Laboratories
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bone research, Ovariectomy-induced bone loss, skeletal disease, TPTx model, thyroparathyroidectomy model, Periosteal injection, Schenk model, Bone defect, Orthopedic, Osteoarthritis, Rheumatoid arthritis, bone densitometry, bone turnover, Dual-Energy X-Ray Absorptiometry, DXA, Peripheral Quantitative Computed Tomography, pQCT
Skeletal Disease Research and Drug Development | Charles River
From early discovery research to preclinical testing and clinical trials, Charles River can assist clients in shortening the development cycle of compounds used to promote bone healing or treat osteoporosis, arthritis, and other skeletal diseases.