Central Nervous System (CNS) Mouse and Rat | Charles River Discovery Services

Parkinson's Disease Model 

Charles River's Parkinson's disease model platform uses manipulation of the unilateral 6-hydroxydopamine (6-OHDA) model in order to take into account both acute and symptomatic effects of Parkinson's disease. In addition, we have, as the product of its own in-house validations, a MPTP model available.

Models for Parkinson's Disease

  • 6-OHDA Medial Forebrain Bundle Model
  • 6-OHDA Striatal Model
  • MPTP Model


Example Study Paradigm of 6-OHDA Striatal Model

Diagram outlining an example study paradigm using our 6-OHDA Striatal model of Parkinson's disease

 

Click here to see a diagram outlining an example study paradigm using our 6-OHDA Striatal model.

 

Data

Quantification of tyrosine hydroxylase (TH) postivie neurons in substantia nigra (SNc) at 14 days after MPTP challenge


Quantification of tyrosine hydroxylase (TH) postivie neurons in substantia nigra (SNc) at 14 days after MPTP challenge


 

Quantification of Dopamine (DA) content in striatum by HPLC at 14 days after MPTP challenge



Quantification of Dopamine (DA) content in striatum by HPLC at14 days after MPTP challenge

 

Amphetamine-Induced net rotational activity in 6-OHDA median forebrain bundle lesioned rats over time



Amphetamine-Induced net rotational activity in 6-OHDA median forebrain bundle lesioned rats over time


Tyrosine hydroxylase postive neurons in substantia nigra (SNc)

Tyrosine hydroxylase postive neurons in substantia nigra (SNc)

For more information about our models used to research Parkinson’s disease, please contact us at askcharlesriver@crl.com.

Charles River also offers an in vitro Parkinson’s disease model. For more information, click here.

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For more information, contact us at:

+33 (0)4 74 01 69 69
askcharlesriver@crl.com

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