Charles River Discovery Services’ model platform for multiple sclerosis (MS) focuses on induction of experimental allergic encephalomyelitis (EAE) in rats and mice. EAE is induced via injection of an inoculum containing either myelin oligodendrocyte glycoprotein (MOG) or proteolipid protein (PLP) in order to produce acute or chronic forms of the disease. Models include acute, progressive or relapsing-remitting disease course with elements of inflammation and neurodegeneration, components relevant to human MS.
Models for Multiple Sclerosis (MS)
- Acute EAE in Rats
- Chronic MOG-induced EAE in Rats
- Chronic MOG-induced EAE in Mice
- Chronic PLP-induced EAE in Mice
Example Study Paradigm of MOG-Induced EAE in Mice
Click here to see a diagram outlining an example study paradigm using our MOG-Induced EAE mouse model.
Data
EAE disease course during 50 days after MOG35-55 inoculation
in naive, EAE and EAE+copaxone treated mice
TNF-α levels in brain at 55 days after MOG35-55 inoculation in naive and EAE mice
TNF-α levels in spinal cord at 55 days after MOG35-55 inoculation in naive and EAE mice
Demyelination in rat spinal cord at 50 days after MOG1-116 inoculation
For more information about our models used to research multiple sclerosis, please contact us at askcharlesriver@crl.com.