Prepulse inhibition of startle is a neurophysiological and behavioral measure of sensorimotor gating. A weaker prestimulus (prepulse) inhibits the reaction of an animal to a subsequent strong startling stimulus (pulse). Abnormal sensory inhibition may reflect a deficit in processing incoming sensory information. Such deficits are often observed in patients suffering from illnesses like schizophrenia.
Charles River Discovery Services uses a model of PCP-induced impairment of prepulse inhibition of startle. An effective reference compound clozapine, a typical antipsychotic drug, is capable of partly reversing the PCP-induced impairment of PPI.
For more information about our model for schizophrenia, please contact us at askcharlesriver@crl.com.
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schizophrenia, Prepulse inhibition, PPI, startle, sensorimotor gating, prestimulus, prepulse, startling stimulus, pulse, clozapine, antipsychotic drugs, PCP-induced, PCP
Schizophrenia Model | Charles River Discovery Services
Abnormal sensory inhibition reflects a deficit in processing incoming sensory information, as seen in people with schizophrenia. Charles River Discovery Services provides a schizophrenia model of PCP-induced impairment of prepulse inhibition of startle.