Renal Sub-Capsule Orthotopic Model
The renal orthotopic model was developed for the efficacy evaluation of novel anti-cancer compounds using a model that mimics the disease process in humans. Cell lines utilized in this model include 786-O and Caki-1.
Effect of Drug A and Drug B on Caki-1 Tumor Volume
Intracranial Orthotopic Model
Intracranial injection of tumor cells mimics clinical responses to tumor growth. Test agent effects are evaluated based on clinical observations and sample analyses. We have used the U87MG human glioma models successfully in mice.
Effect of TMZ or BCNU on TTE (1x106 U87MG Cells)
Intrasplenic Hepatic Colonization Model
Orthotopic seeding of human tumor cell lines allows assessment of tumor development in a hepatic environment and provides efficacy evaluation in a preclinical model mimicking the disease process in humans. This allows for a more representative picture of tumor growth and response to therapy scenario to be realized.
Orthotopic Breast Tumor Model
Either BT474 or MX-1 cancer lines can be injected directly into the mammary fat pad of the mouse in this orthotopic model.
Systemic Leukemia/Lymphoma Model
In this model, Raji-B, MV4-11 and Ramos tumor cells are injected by IV tail vein. Clinical signs associated with progression of tumor include impairment of hind limb function, ocular proptosis and weight loss.
For more information about our orthotopic cancer models, please contact us at askcharlesriver@crl.com.