Drug Discovery Research and Screening Services | Charles River

ADME Screening 

Whether you have one compound or a library of compounds requiring drug metabolism assessment, the skilled scientists at Charles River can design, conduct and interpret the in vivo pharmacokinetic/ADME components of your program as part of our streamlined non-GLP screening services. Quick study initiation, multiple species, resident animal colonies (with chronic surgical models included) and various dose regimens and administration routes, plus bioanalytical support, provide the necessary tools you need to rapidly identify and optimize potential drug candidates.

Available Services 

  • Bioavailability
  • Biliary excretion
  • Mass balance
  • Tissue distribution
  • Placental transfer
  • Bioequivalence
  • Dose ranging
  • Linearity
  • Proportionality
  • Single, multiple and cassette dosing
  • Metabolite profiling


Surgical Models 

  • Vascular access ports
  • Chronic bile duct cannulation in nonrodent species
  • Intestinal cannulation
  • Portal vein cannulation
  • Cardiovascular telemetry 


Laboratory Support

  • Formulation development
  • Research-grade assays


For more information about our in vivo pharmacokinetic/ADME screening services, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.  

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For more information, contact us at:

+33 (0)4 74 01 69 69
askcharlesriver@crl.com

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Charles River Laboratories, Inc.