Neurovascular activity and coupling (hemodynamic response to metabolic activity) may be detected utilizing blood oxygenation level-dependent (BOLD) effect in functional MRI studies. Fast imaging sequences detect well-localized activations (e.g., at somatosensory cortex after forepaw stimulation).
Cerebral activity following acute drug administration (single challenge) and CNS adaptation to medication may be detected using BOLD paradigm or relative CBV (rCBV) as detected by MION-MRI. Results provide insight into brain physiology and neuropharmacological mechanisms.
For more information about our functional MRI (fMRI) and pharmacological MRI (phMRI) services, contact us at askcharlesriver@crl.com.
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Neurovascular activity, coupling, hemodynamic response, blood oxygenation level-dependent, BOLD, functional MRI, Cerebral activity, relative CBV, rCBV, CBV, MION-MRI, Pharmacological MRI, phMRI
Functional MRI (fMRI) & Pharmacological MRI (phMRI) | Charles River
Imaging technologies, such as functional Magnetic Resonance Imaging (fMRI) and pharmacological MRI (phMRI), can increase lead candidate selection efficiency by providing more highly predictive data early in the drug development process.