In vitro Services | Charles River Discovery Services

Analytical Services 

Charles River offers a wide range of study-specific analytical services by ELISA, EIA, Western blotting and HPLC.

 

    ELISA / EIA / Activity Assay

    • IL-1β ELISA
    • TNF-α ELISA
    • IL-6 ELISA
    • Aβ1-40 ELISA
    • Aβ1-42 ELISA
    • total TAU ELISA
    • p-TAU ELISA
    • PGE2 ELISA
    • P-ser9-GSK3β ELISA
    • CGRP ELISA
    • BDNF ELISA
    • eNOS ELISA
    • IGF-I ELISA
    • EPO ELISA
    • TGF-β ELISA
    • IDE activity assay
    • LDH Measurement
    • Determination of Nitrite (Griess)
    • Protein Determination Assay
 

Western Blotting

  • C99, C83 and holoAPP
  • p-TAU / total Tau
  • Synaptophysin
  • NF-kappaB p65
  • GLT-1 (GLAST)
  • GAPDH


HPLC

  • DA, DOPAC and HVA
  • NA
  • 5HT
  • Glutamate
  • Ach

 

 

Protein expression and phosphorylation in tissue or cell culture samples can
be studied using Western blotting. 

Western blot


DAPT significantly decreases the soluble Aβ1-40 and Aβ1-42 levels in the hippocampus of Tg2576 mice.

Hippocampal Aβ1-40 in 5-Month-Old Tg2576 Mice

 

Hippocampal Aβ1-40 in 5-Month-Old Tg2576 Mice

 
Hippocampal Aβ1-42 in 5-Month-Old Tg2576 Mice


Hippocampal Aβ1-42 in 5-Month-Old Tg2576 Mice




Striatal dopamine level is significantly depleted in mice after MPTP-dosing.

Striatal dopamine level in naive mice

Striatal dopamine level in mice after MPTP dosing

 

For more information about our analytical services, please contact us at askcharlesriver@crl.com.

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For more information, contact us at:

+33 (0)4 74 01 69 69
askcharlesriver@crl.com

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