Charles River provides comprehensive pathology-based services in the fields of metabolic bone disease and orthopedics. Our staff has expertise in the preparation of thick and thin sections of plastic-embedded undecalcified tissue, cryotomy of undecalcified specimens, and the application of computer-assisted image analysis for histomorphometric/histologic measurements. The image analysis can quantify structural findings in both hard and soft tissue, as well as fluorochrome label-derived dynamic changes in bones.
Our fully integrated approach to bone pathology assists pharmaceutical, biotechnology, and medical device companies in study design, development strategies, regulatory submissions, and project execution for therapeutics designed for the treatment and prevention of osteoporosis, osteoarthritis, and bone regeneration. Our experienced pathologists, together with a team of highly trained technicians, provide focused and broad-based services in bone pathology:
- Histomorphometry
- Histology
- Molecular biology
Additional services in the area of bone and joint research include diagnostic and quantitative imaging and biomechanical strength testing.