Charles River offers a comprehensive support program for the implementation and evaluation of developmental and reproductive toxicology studies that involve the assessment of both male and female reproductive toxicology, as well as the assessment of both in vivo and in vitro developmental toxicology.
Our mobile services are unique in the industry because we offer specialists, all instrumentation, and validated technologies to conduct critical end-point measurements at your facility. Our expertise in protocol design, study management, and data interpretation provides a full range of services designed to include all aspects of developmental and reproductive studies.
In the development of new drugs or other chemical agents, it is important to obtain an indication of potential toxicity as early as possible. Typically, information on potential reproductive toxicity is not available until later in the product development process. However, Charles River offers specialized in vitro developmental toxicity testing utilizing the Whole Embryo Culture (WEC) technique. With more than 50 years of cumulative experience, we have a first-class team of professional pathology and toxicology staff available to support you in your developmental and reproductive toxicity testing.
Services
- Multi-species, fully automated sperm analysis
- Mobile services provide on-site motility, necropsy, and tissue collection
- Evaluation of male reproductive toxicity endpoints
- Maternal toxicity
- Fetal morphological examinations with mobile computer data system
- Soft tissue examinations
- Skeletal staining and evaluation