Our In Vitro Services provide support in metabolic, toxicokinetic and bioanalytical investigations with both qualitative and quantitative data. In vitro studies can be conducted with both radiolabelled and non-radiolabelled test articles as required.
Services
- Species variation in metabolism - hepatic and extrahepatic whole cells (e.g., hepatocytes) and subcellular fractions (e.g., microsomes)
- Drug-drug interactions (CYP450 inhibition and induction)
- Drug absorption and kinetics (Caco-2 cells)
- Protein binding (equilibrium dialysis or ultrafiltration as well as high-throughput HSA and AGP assay)
- Ex vivo induction studies using validated CYP-specific assays and Western blotting
- CYP450 reaction phenotyping
- Dermal absorption
- Metabolite stability, profile, and identification
- hERG channel inhibition (QT prolongation)
- Aqueous solubility
- Cell viability (cytotoxicity)
- Cell proliferation
- Enzyme and immunoassays (ELISA, RIA, DPP-IV, and more)
For additional information, contact us at askcharlesriver@crl.com.
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In Vitro, radiolabelled, non-radiolabelled, metabolism, metabolic, hepatic, extrahepatic, hepatocytes, microsomes, Drug-drug interactions, CYP450, absorption, kinetics, Caco-2, Protein binding, equilibrium dialysis, ultrafiltration, HAS, AGP, CYP, Western blot, phenotyping, Dermal absorption, metabolite, metabolites, hERG, QT prolongation, solubility, Cell viability, cytotoxicity, Cell proliferation, immunoassays, ELISA, RIA, DPP-IV
In Vitro Services | Charles River
Our In Vitro Services provide support in metabolic, toxicokinetic and bioanalytical investigations with both qualitative and quantitative data. In vitro studies can be conducted with both radiolabelled and non-radiolabelled test articles.