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Charles River has extensive experience conducting inhalation toxicology studies for the pharmaceutical, chemical, and biotechnology industries. Since the implementation of GLPs in 1978, studies ranging from acute to carcinogenicity have been performed utilizing a variety of species for materials of different forms, such as powder, liquid, metered dose inhaler, and vapor.
Our scientific and technical staff has a strong knowledge base in testing program design. Our experience includes the selection of drug formulation and delivery systems, the estimation of dosage in animal studies, new therapeutic areas, and special studies to demonstrate efficacy or pharmacotoxicity. With the largest inhalation toxicology facilities in the world, we have incorporated rodent inhalation dosing rooms with adjacent husbandry space, as well as constructed a dedicated section for non-rodent studies. Each dosing suite is equipped with customized generation and exposure systems for delivery of test atmospheres.
We have additional expertise in micronizing and blending powder formulations and characterizing a wide range of inhaled compounds, including liquids, powders, vapors, and gases.
Study Types
- Nose-only, oronasal, and head-only
- Acute to chronic toxicity, plus carcinogenicity
- Neonatal inhalation
- Reproductive inhalation
- Intratracheal
- Intranasal
- Anti-asthmatic efficacy
- Immunologic sensitization via inhalation
- Radiolabelled aerosol studies
Related Information
Webinar Replay - Preclinical Pulmonary Inflammation Models (October 2010)
Additional information about our Inhalation Toxicology capabilities is available in The SourceSM, our new online scientific and educational information center. To register for The SourceSM, please click here. If you are already a member, click here to login.
If you have any questions, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.
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Inhalation toxicology, inhalation toxicology studies, inhalation toxicity testing, inhalation studies, Intranasal delivery, Anti-asthma efficacy, Radiolabeled aerosol deposition, Respiratory physiology assessment, Antiasthmatics, Anticholinergics, Mucolytics, nose-only flow-through, nose-only dosing, Intranasal administration, nasal instillation, Metered dose inhalers, Dry powder inhalers, Nebulizers, atomizers, Aerosols, Emulsion sprays, Vapors, Atmosphere characterization, particle size distribution, gravimetric assessment, temporal homogeneity evaluation, chemical analysis
Inhalation Toxicology Studies | Preclinical Services | Charles River
Charles River conducts inhalation toxicology studies for dry powders, liquids, and gases. Our experience includes the selection of drug formulation and delivery systems, estimation of dosage, and studies to demonstrate efficacy or pharmacotoxicity.