research animal models

ORIGIN
The Apoe^tm1Unc mutant strain was developed in the laboratory of Dr. Nobuyo Maeda at The University of North Carolina at Chapel Hill. The 129-derived E14Tg2a ES cell line was used. The plasmid used is designated as pNMC109 and the founder line is T-89 in the primary reference. The C57BL/6J strain was produced by backcrossing the Apoe^tm1Unc mutation 10 times to C57BL/6J mice. Pedigree mice from The Jackson Laboratory were transferred to Charles River Laboratories UK in October 2004. The mice are a useful model of hypercholesterolaemia and show a marked increase in total plasma cholesterol levels that are unaffected by age or sex. Fatty streaks in the proximal aorta are found at 3 months of age. The lesions increase with age and progress to lesions with less lipid but more elongated cells, typical of a more advanced stage of preatherosclerotic lesion. Recent studies indicate that Apoe deficient mice have altered responses to stress, impaired spatial learning and memory, altered long-term potentiation, and synaptic damage.

COAT COLOR Black

JAX^® Mice Stock Number 002052

CONTROL JAX^® Mice Strain: C57BL/6J

BREEDING LOCATION
Italy, UK

ADDITIONAL INFORMATION
For more information, including phenotyping data, on JAX® ApoE Knockout mice, please visit http://jaxmice.jax.org/strain/002052.html.

Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX® Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.

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