NOMENCLATURE C3H/HeNCrl
ORIGIN
From a cross of a Bagg albino female and a DBA male by Strong in 1920. A litter of 4 females and 2 males sent to Andervont in 1930; then to Heston at F35. To NIH in 1951 from Heston at F57. To Charles River Laboratories USA from NIH in 1974. Caesarian derived in 1975. 85% hepatomas at 14 months. This is an MMTV negative strain and hence does not show high incidence of mammary tumours. Resistant to Leishmania infection. High complement activity. Retinal degeneration allele (rd) is carried on chromosome 5. Mated females are highly susceptible (89%) to cardiac calcinosis.
HAPLOTYPE H2k
COAT COLOR Agouti
BREEDING LOCATION
Germany, UK, Italy, Japan, US
ADDITIONAL INFORMATION
For more information about C3H mice, please contact us at info@eu.crl.com.