ORIGIN
Most commonly called the NIH-III, it was developed at NIH. In addition to the nude gene, which results in the absence of thymus and T-cell function, this mouse has two other mutations important in regulating the function of the immune system. These are designated as x-linked immune defect (xid) and beige (bg). The xid mutation affects the maturation of T-independent B lymphocytes. It has been demonstrated that bg homozygotes have defective natural killer (NK) cells that are cytotoxic in vitro to tumor cells. However, the extent of the T-independent B lymphocyte and NK cell deficiencies in the NIH-III have not been established.
*Note: Heterozygous animals are not immunodeficient and are haired.
COAT COLOR Hairless, light to dark gray pigmented skin
RESEARCH APPLICATION
tumor biology and xenograft research
BREEDING LOCATION
US
ADDITIONAL INFORMATION
For more information about NIH-III Nude mice, please contact us at info@eu.crl.com.