research animal models
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Nociceptin Receptor (OPRL1) Knockout Rat | Charles River
Charles River provides research animals, including genetically engineered models like the Nociceptin Receptor (OPRL1) Knockout rat, for use in basic research and nonclinical drug discovery and development.
 overviewpricing & literature
OPRL1 RatWI(Han).BN-OPRL11Hubr/Crl
ORIGIN
This strain was created in the laboratory of Dr. Edwin Cuppen at the Hubrecht Institute in the Netherlands. Biochemical characterization revealed that the OPRL1 functional protein (Nociceptin Receptor) is completely absent in homozygous knock-out rats and that there is a gene dose-dependent reduction in the expression and function of the Nociceptin Receptor in heterozygous knock-out rats. No adaptative change in other opioid receptor levels (kappa, delta, mu) could be demonstrated.
RESEARCH APPLICATION
Neurobiology, Sensorineural (pain), Behavioral and learning defects, Toxicology (drug/compound testing), Addiction
BREEDING LOCATION
France
ADDITIONAL INFORMATION
For more information or to order OPRL1 rats, contact catalogue@genoway.com
overviewpricing & literature
Informational Resources: OPRL1 Rat
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