ORIGIN
This model was isolated from a C57BL/6NCrl colony in a Charles River Laboratories barrier facility in the United States in 2005. The mutation was mapped to a region within less than 2 cM of the leptin receptor on Chr 4. Lack of leptin receptor protein. Het x Het mating.
STRAIN CODE 457 (OBESE), 464 (LEAN +/?)
COAT COLOR Black
RESEARCH APPLICATION
obesity, hyperinsulinemia, insulin resistance, dyslipidemia, metabolic syndrome, leptin receptor deficiency, fatty liver disease
CONTROL THE POUND MOUSE™ lean or the standard C57BL/6NCrl
BREEDING LOCATION
US
ADDITIONAL INFORMATION
For more information about THE POUND MOUSE™, please contact us at info@eu.crl.com.