ORIGIN
This mutation occurred in the laboratory of Dr. Simon Koletsky in 1969 at Case Western Reserve University School of Medicine. It was developed from a cross between a hypertensive female rat and a normotensive male Sprague Dawley rat. The colony was maintained as brother x sister matings in a closed colony at Case Western Reserve University School of Medicine since 1971. To Genetic Models, Inc. in 2000. To Charles River in 2001.
STRAIN CODE 375 (OBESE), 376 (LEAN +/?)
LEAN SHROB RATS: The lean phenotype in the SHROB rat model exhibits most of the characteristics observed in the obese animal.
COAT COLOR White (albino)
RESEARCH APPLICATION
hypertension, hyperinsulinemia, obesity, nephropathy, metabolic syndrome, hyperlipidemia
BREEDING LOCATION
US
ADDITIONAL INFORMATION
For additional information about Spontaneously Hypertensive Obese (SHROB) rats, please contact us at info@eu.crl.com.