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Spontaneously Hypertensive (SHR) Rat, the most commonly used genetically hypertensive rat model

Spontaneously Hypertensive (SHR) Rat

SHR/NCrl

ORIGIN
Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure. Brother x sister mating with continued selection for spontaneous hypertension was then started. To NIH in 1966 from Okamoto at F13. To Charles River from NIH in 1973 at F32.

COAT COLOR White (albino)

RESEARCH APPLICATION
genetic hypertension, hypertensive drug research, ADHD model, safety and efficacy testing

MHC HAPLOTYPE RT1k

BREEDING LOCATION
Germany, UK, US

ADDITIONAL INFORMATION
For more information about Spontaneously Hypertensive (SHR) rats, please contact us at info@eu.crl.com.


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