Benefits and Applications

Capture Compound Mass Spectrometry (CCMS) benefits and applications include the following:

Compound profiling

CCMS-mediated target ID provides:

  • Identified targets for phenotypic compound-finding campaigns
  • ID of binding site and mode of interaction
  • Targets in any cellular compartment (e.g., GPCRs, ion channels, cytoplasmic signaling proteins and enzymes, nuclear proteins)
  • Proteins of low abundance
  • Deconvolution of targets for mechanism of action, adverse events, or toxicities in any tissue or species
  • Novel mechanistic targets for compound re-positioning
Chemistry decision making
Managing risk
Supporting projects across discovery and development

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Cells expressing green fluorescent protein (GFP)

Phenotypic Screening

Charles River has extensive experience screening in disease-relevant human primary cells with functional readouts in medium- and high-throughput.