In Vitro ADMET Assays

In recent years, the pharmaceutical industry has begun to focus on in vitro ADMET parameters as a major cause for many drug failures. ADMET, which stands for absorption, distribution, metabolism, elimination, and toxicity, is a set of factors that describes how a drug behaves in the human body. The goal throughout the drug discovery process is to predict at an early stage which compounds not only possess good binding affinity for a specific target, but also pass the tests for good ADMET properties in terms of bioavailability and safety.

The in vitro ADMET assays offered by Charles River assist to efficiently identify and focus efforts on compounds that have the greatest likelihood of success.  Our high throughput automated systems provide key information in the areas of metabolism, toxicity, and physicochemical characteristics, with an emphasis on quality and rapid turnaround. Recognized throughout the industry for both scientific and automation expertise, the scientists at Charles River conduct a wide range of quality in vitro ADMET assays.

Services

• Aqueous solubility
• Cytochrome P450 enzyme inhibition
• Cytochrome P450 reaction phenotyping
• Cell proliferation & cytotoxicity
• Drug interaction
• Enzyme assays                                                                                
• hERG inhibition
• Immunoassays: ELISAs, RIAs (commercial assay kits)
• Melanin binding
• Cell permeability assays (CaCo-2)
• Metabolic stability
• Metabolite profiling
• Metabolite assessment

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

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