Charles River - Preclinical Services: In Vivo PK/ADME Studies

In Vivo PK/ADME Screening

Charles River Laboratories is an industry leader in conducting in vivo pharmacokinetic and ADME studies. Our skilled scientists can design and interpret the drug metabolism components of your program, which include the evaluation of various dose regimens and administration routes using both small and large animal species. Charles River's streamlined lead optimization services can help prioritize and accelerate the drug discovery process for compound ranking and lead candidate selection.

We have some of the largest nonrodent resident animal colonies in the industry, with numerous chronic surgical models included, offering the quickest initiation for all study types.

Service Offerings

Bioavailability
Biliary excretion
Mass balance
Tissue distribution
Placental transfer
Bioequivalence
Dose ranging
Linearity
Proportionality
Single, multiple, and cassette dosing
Metabolite profiling

Surgical Models

Vascular access ports
Chronic bile duct cannulation in large animals
Intestinal cannulation
Portal vein cannulation
Cardiovascular telemetry

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

All news items

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ASK CHARLES RIVER,
or call 1-877-CRIVER1.