Pharmacology Efficacy Models

Charles River Laboratories conducts pharmacology proof-of-principle studies used in early stage preclinical development to help determine test article efficacy for a specific clinical indication. Good evidence of efficacy in an animal model of human disease and a screening panel of relevant in vitro and in vivo toxicity tests provide additional confidence in lead candidate selection. Our scientists can evaluate the safety and efficacy in the relevant in vivo disease models, thereby facilitating the overall developmental process.

Charles River offers a range of pharmacology efficacy models spanning the following areas:

• Inflammation
• Metabolic disease
• Oncology
• Neurology
• Cardiovascular
• Ocular
• Dermal
• Organ transplantation
• Respiratory
• Tissue repair and wound healing
• Osteoporosis
• Osteoarthritis
• Rheumatoid arthritis

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