Toxicokinetics

We provide bioanalytical support for samples generated in toxicology studies, and the resultant test material concentration data can be interpreted by our Pharmacokinetics staff using industry-standard WinNonlin^® software. Both non-compartmental and compartmental approaches are available. We offer this as an integrated service, where all aspects of the study are managed within our own laboratories, or as a stand-alone service, which enables analysis of concentration data generated elsewhere by the sponsor.

Toxicokinetic parameter estimation output includes a comprehensive text interpretation of the data, as required.

In addition, we can address preclinical-to-clinical considerations (e.g., allometric scaling) when planning first-time-in-man (FTIM) studies.

See also our Preclinical Pharmacokinetics and  Clinical Pharmacokinetics pages.

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

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