Formulation and Analytical Chemistry

Formulations (dietary, gavage, inhalation, parenteral, and topical) are analyzed to determine the concentration of test material using a variety of chromatographic and spectroscopic techniques. Additionally, we offer analytical services in support of inhalation toxicology studies, including determination of particle size distribution, analysis of inhalation blends for confirmation of homogeneity and concentration, and analysis of inhalation chamber atmospheres.

Methods typically employed include:

• HPLC – High-performance liquid chromatography
• UV-Vis spectroscopy
• CE - Capillary electrophoresis
• GC - Gas chromatography
• GC/MS – Gas chromatography/mass spectrometry
• LC/MS/MS – Liquid chromatography/mass spectrometry
• AAS - Atomic absorption spectrophotometry
• FTIR – Fourier transform infrared spectroscopy
• Karl Fischer

Bulk test articles are analyzed for determination of identity, purity, and stability to support GLP preclinical studies. Adhering to strict regulatory guidelines, test article receipt, storage, distribution, use, and disposition are controlled by dedicated staff with several facilities operating a barcode system for identification and monitoring of materials. 

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Perpetual Motion in Preclinical Services US

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